Publication:


abstract

BACKGROUND:

Th2 cells play an important role in intermittent allergic rhinitis (IAR). Interleukin (IL)-33 stimulates the production of Th2-associated cytokines. IL-33 binds to ST2 receptor which is highly expressed on mast cells and selectively on Th2 cells. IL-33 and ST2 might be involved in the Th2-mediated immune response.

OBJECTIVE:

We analyzed the Serum level of IL-33 and its receptor ST2 in patients with IAR sensitive to grass and/or tree pollen to assess if the serum level of IL-33 and/or ST2 may be a marker of the disease severity.

METHODS:

IL-33, ST2 and total immunoglobulin (Ig) E were measured in sera of patients with IAR sensitive to birch and/or grass pollen and in patients with controlled bronchial asthma and in non-allergic controls. IAR severity was assessed by total nasal symptom score.

RESULTS:

Serum levels of IL-33 in patients with IAR were comparable with patients with bronchial asthma and were significantly higher in patients with IAR (P = 0.0035) and in patients with bronchial asthma (P = 0.008) than in controls. Serum levels of IL-33 correlated with disease severity.

CONCLUSION:

elevated level of IL-33 in sera of patients with IAR sensitive to tree and/or grass pollen and the correlation of IL-33 with the disease severity suggest that IL-33 is involved in the pathogenesis of intermittent allergic rhinitis.

Related Articles
The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis.
Clin Exp Allergy. 2012
The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis.
Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T. Clin Exp Allergy. 2012 Feb; 42(2):218-28.
Allergen-reactive antibodies are found in nasal fluids from patients with birch pollen-induced intermittent allergic rhinitis, but not in healthy controls.
Allergy. 2003
Allergen-reactive antibodies are found in nasal fluids from patients with birch pollen-induced intermittent allergic rhinitis, but not in healthy controls.
Benson M, Reinholdt J, Cardell LO. Allergy. 2003 May; 58(5):386-92.
Intracellular production of IL-2, IL-4 and IFN-gamma by peripheral blood CD3+ cells in intermittent allergic rhinitis.
Inflamm Res. 2005
Intracellular production of IL-2, IL-4 and IFN-gamma by peripheral blood CD3+ cells in intermittent allergic rhinitis.
Glück J, Rogala B, Mazur B. Inflamm Res. 2005 Feb; 54(2):91-5.
Review New insights into the role of cytokines in asthma.
J Clin Pathol. 2001
Review New insights into the role of cytokines in asthma.
Renauld JC. J Clin Pathol. 2001 Aug; 54(8):577-89.
Review IL-5 and IL-5 receptor in asthma.
Mem Inst Oswaldo Cruz. 1997
Review IL-5 and IL-5 receptor in asthma.
Kotsimbos AT, Hamid Q. Mem Inst Oswaldo Cruz. 1997; 92 Suppl 2:75-91.