Publication:


abstract

PURPOSE:

A case of acute pancreatitis associated with Liraglutide is reported.

SUMMARY:

A 53-year-old African-American man (height, 185.4 cm; weight, 108.6 kg) with type 2 diabetes mellitus arrived at the emergency department (ED) with new-onset intolerable abdominal pain in the right upper quadrant and left upper quadrant that had appeared suddenly and lasted two to three hours. He had nausea but no vomiting, with tenderness in the epigastric region. In the ED, his serum amylase concentration was found to be extremely elevated (3,963 units/L), as was his serum lipase concentration (>15,000 units/L). In addition to type 2 diabetes, his medical history included hyperlipidemia, hypertension, peripheral neuropathy, erectile dysfunction, and obesity. His home medications included aspirin 81 mg orally daily, metformin 1000 mg orally every morning and 1500 mg every evening, simvastatin 80 mg orally daily at bedtime, tadalafil 20 mg orally as needed, glimepiride 4 mg orally twice daily, and liraglutide 1.2 mg subcutaneously daily. Two months before his arrival to the ED, the patient's dosage of liraglutide was increased from 0.6 to 1.2 mg subcutaneously daily. Radiographic data were obtained, and acute pancreatitis was diagnosed. Liraglutide was discontinued indefinitely after ruling out elevated triglycerides as the cause of pancreatitis. The patient was initiated on standard therapy for acute pancreatitis and discharged eight days later with complete resolution of symptoms and normal laboratory test values.

CONCLUSION:

A 53-year-old man with type 2 diabetes mellitus developed a probable case of liraglutide-induced acute pancreatitis after receiving the drug for approximately two months.

Related Articles
Acute pancreatitis associated with liraglutide.
Ann Pharmacother. 2011
Acute pancreatitis associated with liraglutide.
Lee PH, Stockton MD, Franks AS. Ann Pharmacother. 2011 Apr; 45(4):e22. Epub 2011 Apr 12.
Hypertriglyceridemia-induced acute pancreatitis treated with insulin and heparin.
Am J Health Syst Pharm. 2012
Hypertriglyceridemia-induced acute pancreatitis treated with insulin and heparin.
Twilla JD, Mancell J. Am J Health Syst Pharm. 2012 Feb 1; 69(3):213-6.
Amiodarone-induced neurotoxicity.
Am J Health Syst Pharm. 2009
Amiodarone-induced neurotoxicity.
Willis MS, Lugo AM. Am J Health Syst Pharm. 2009 Mar 15; 66(6):567-9.
Review Elevated hepatic transaminases associated with telithromycin therapy: a case report and literature review.
Am J Health Syst Pharm. 2008
Review Elevated hepatic transaminases associated with telithromycin therapy: a case report and literature review.
Bolesta S, Roslund BP. Am J Health Syst Pharm. 2008 Jan 1; 65(1):37-41.
Review Repaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus.
Pharmacoeconomics. 2004
Review Repaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus.
Plosker GL, Figgitt DP. Pharmacoeconomics. 2004; 22(6):389-411.